Dragon Promoter Finder

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Dragon Promoter Finder

Dragon Promoter Finder Ver. 1.5 is an improved version of the Dragon Promoter Finder program. It generally produces 2.3 times less false positive predictions than the version 1.3. It searches for and locates promoters in anonymous genomic size DNA sequences. The program attempts to recognize the exact location of the transcription start site (TSS), i.e. the +1 position relative to the TSS. The analysis is strand specific. The algorithm is designed and tuned for a high specificity search, meaning that, in general, it will produce a small number of false positive predictions (see Estimated accuracy). The main difference in the algorithm is that the models are now specialized for C+G-rich and for C+G-poor sequences. In one of the additional features that allow for the analysis of the selected region around the predicted TSS, the TFSEARCH (Y. Akiyama, "TFSEARCH: Searching Transcription weight gain Factor Binding Sites", http://www.rwcp.or.jp/papia/ ) is replaced by the Matchä tool which uses a library of mononucleotide weight matrices from the TRANSFAC databse (public version 6.0) (E. Wingender, X. Chen, E. Fricke, R. Geffers, R. Hehl, I. LieBich, M. Krull, V. Matys, H. Michael, R. Ohnhauser, M.Prüβ, F. Schacherer, S. Thiele and S. Urbach. The TRANSFAC system on gene expression regulation. Nucleic Acids Research 2001. Vol. 29, No. 1: 281-283). Users of the system cannot search the TRANSFAC Professional database on our site, but can use the official one at http://www.biobase.de/

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